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Pharmaceuticals

Lilly Halts Tests On Alzheimer’s Candidate

by Rick Mullin
August 23, 2010 | A version of this story appeared in Volume 88, Issue 34

Eli Lilly & Co. announced it is halting development of one of its experimental late-stage Alzheimer’s disease treatments because two preliminary Phase III clinical trials indicate that the drug may worsen cognition and the ability to perform daily tasks. The developmental drug, semagacestat, is a γ-secretase inhibitor of amyloid-β, a peptide responsible for plaques that form on the brains of Alzheimer’s patients (C&EN, April 5, page 12). The company says its decision does not affect the Phase III clinical trials of its other Alzheimer’s candidate, solanezumab.

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