Volume 88 Issue 39 | p. 48 | Concentrates
Issue Date: September 27, 2010

Unnatural Amino Acid Spurs Polymer Growth

A synthetic amino acid containing a polymerization initiator promotes formation of protein-polymer bioconjugates
Department: Science & Technology
News Channels: JACS In C&EN
Keywords: materials, polymers, proteins, unnatural amino acids

An unnatural amino acid containing a polymerization initiator allows the easy formation of protein-polymer bioconjugates, according to a paper in the Journal of the American Chemical Society (DOI: 10.1021/ja104493d). Ryan A. Mehl of Franklin & Marshall College, in Lancaster, Pa., and coworkers designed the amino acid 4-(2ʹ-bromoisobutyramido)­phenylalanine as an initiator for atom-transfer radical polymerization (ATRP). The molecule is genetically installed at defined sites in a . . .

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