Volume 88 Issue 44 | p. 25 | Concentrates
Issue Date: November 1, 2010

Turning Up The Heat On DNA Methylation

Epigenetics: High-resolution melting distinguishes different methylation states of DNAs at the genomic level
Department: Science & Technology
Keywords: Methylsiloxanes, DNA methylation, epigenetics, epigenetics, genome

Although methyl groups are uncharged and relatively small, they exert enormous influence over genomes. When enzymes add a methyl group to the DNA base cytosine, the modification tends to repress gene expression. Meanwhile, undermethylated genes are often highly expressed. It's no wonder then that researchers are keen to study this simple modification.

But for most molecular techniques, methylated DNA bases look just like their unmethylated counterparts. Now a study finds that researchers can detect methylation . . .

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