Issue Date: November 1, 2010
Turning Up The Heat On DNA Methylation
Although methyl groups are uncharged and relatively small, they exert enormous influence over genomes. When enzymes add a methyl group to the DNA base cytosine, the modification tends to repress gene expression. Meanwhile, undermethylated genes are often highly expressed. It's no wonder then that researchers are keen to study this simple modification.
But for most molecular techniques, methylated DNA bases look just like their unmethylated counterparts. Now a study finds that researchers can detect methylation . . .
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