Volume 89 Issue 16 | p. 35 | Concentrates
Issue Date: April 18, 2011

Meth Vaccine Hunt Revamped

New methamphetamine analogs elicit antibodies to squelch the addictive drug’s activity
Department: Science & Technology
Keywords: vaccine, drug abuse, methamphetamine, organic chemistry, medicinal chemistry

The search for vaccines that squelch the addictive drug methamphetamine is all about structure, a new report suggests (J. Am. Chem. Soc., DOI: 10.1021/ja108807j). No approved meth drug-abuse therapies exist, and efforts to develop vaccines that would keep the drug from reaching the brain where it is active have been largely ineffective. Kim D. Janda and colleagues at Scripps Research Institute have now used molecular modeling to guide their vaccine hunt. . . .

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