Volume 89 Issue 26 | p. 31 | Concentrates
Issue Date: June 27, 2011

Herpes-related octasaccharides inhibit infection

Department: Science & Technology
Keywords: herpes simplex virus, heparan sulfate

Herpes simplex virus, which causes skin and mucous-membrane lesions, infects cells by interacting with heparan sulfate found on cell surfaces. Researchers in Taiwan have now synthesized octasaccharides resembling those glycans, and the oligomers turn out to inhibit viral infection by competing with cell-surface virus-glycan interactions. The work was carried out by Shang-Cheng Hung and coworkers at Academia Sinica (Nat. Chem.,DOI: 10.1038/nchem.1073). It is known that attachment of herpesvirus to cell-surface heparan sulfate proteoglycans enables . . .

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