If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.


Biological Chemistry

Polymers Shepherd RNA Drugs

by Aaron A. Rowe
September 5, 2011 | A version of this story appeared in Volume 89, Issue 36

A new polymeric drug delivery system inspired by bacterial toxins could aid medical use of RNA drugs, which often get inactivated shortly after they are introduced into cells. Cationic polymers have been used as nucleic acid delivery vehicles for more than a decade, but many of them don’t work well enough for medical applications. After entering cells, the polymers and their payloads often get trapped within endosomes and lysosomes, where they are rendered inactive. Now, a team led by Patrick S. Stayton of the University of Washington, Seattle, has developed RNA-binding copolymer micelles with domains that are neutral or negatively charged under ambient conditions. At standard physiological pH, carboxylic acid groups in these polymers have a negative charge. Endosomes and lysosomes have acidic interiors that can protonate these groups. Once they have been protonated, the polymers adopt a new conformation that disrupts the structure of the compartments, releasing their cargo. The work “addresses one of the critical aspects of siRNA delivery,” said Peter D. Senter of Seattle Genetics, namely keeping drug molecules out of cell endosomes and lysosomes.


This article has been sent to the following recipient:

Chemistry matters. Join us to get the news you need.