Volume 89 Issue 40 | p. 11 | News of The Week
Issue Date: October 3, 2011

Tweezing Apart Amyloids

Therapeutics: Small molecule sticks to lysine to unglue protein aggregates
Department: Science & Technology
Keywords: amyloid, CLR01, protien folding

A clawlike molecule that can unravel the aberrant protein snarls behind diseases such as Alzheimer’s and Parkinson’s may serve as the basis for a new strategy to treat a broad range of protein-misfolding diseases (J. Am. Chem. Soc., DOI: 10.1021/ja206279b).

The protein clumps associated with these diseases are called amyloids. They form when normal proteins in the cell unfold and then . . .

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