Volume 89 Issue 51 | p. 14
Issue Date: December 19, 2011

Cover Stories: Chemical Year In Review 2011

Molecular Machine’s Workings Visualized

Chemical labeling and microscopy technique demonstrates its power on the spliceosome
Department: Science & Technology
Keywords: spliceosome, fluorescence, mRNA, alternative splicing

A fluorescence microscopy method that marks biomolecules with organic dyes made it possible this year to understand the workings of complex biomolecular processes at the single-molecule level. The technique was developed by Melissa J. Moore of the University of Massachusetts Medical School, Jeff Gelles of Brandeis University, Virginia . . .

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