Issue Date: April 30, 2012
Blood Typing Made Simple
For anyone who has ever wondered what their blood type is, a new paper-based device will literally write the answer, providing an inexpensive and unambiguous way to determine blood type (Angew. Chem. Int. Ed., DOI: 10.1002/anie.201201822).
The presence or absence of certain antigens on red blood cells determines a person’s blood type. Specific antibodies will react with these antigens and make the red blood cells clump. Researchers led by Wei Shen, of Australia’s Monash University, use an ink-jet printer to apply these antibodies in the shapes of letters A, B, and X as well as a vertical line onto postage-stamp-sized pieces of paper towel. O and rhesus-negative blood types don’t have antigens that react with these antibodies, so the researchers preprint an O in the same spot as the X and a horizontal line intersecting the vertical line on the paper in red waterproof ink.
Place a few drops of blood on the paper, wash it with saline, and in under a minute,
Shen got the idea after seeing the film adaptation of J. K. Rowling’s book “Harry Potter and the Chamber of Secrets,” in which the characters query a diary that responds in writing. Shen realized technology he had previously helped develop could be modified to respond in writing to the question: What’s my blood type?
“The ability to form letters that directly report blood type makes it possible for nonexperts to interpret the results rapidly, which is of particular importance in rapid-response scenarios,” comments John D. Brennan, an expert in bioanalytical chemistry at McMaster University in Ontario. “This method also shows the advantage of implementing simple ink-jet printers to produce paper assays rather than conventional lateral flow printers, which produce only lines.”
- Chemical & Engineering News
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