Acetaminophen Toxicity | Chemical & Engineering News
Volume 90 Issue 19 | p. 2 | Letters
Issue Date: May 7, 2012

Acetaminophen Toxicity

Department: Letters

Stephen A. Munk hypothesizes that acetaminophen owes its toxic effects (including a recently discovered link to asthma) to a mechanism involving metabolic oxidation of its hydroquinone-like structure followed by reaction with essential nucleophiles and glutathione depletion (C&EN, March 26, page 7). He suggests that “this line of work is worth pursuing,” but this mechanism is already well-known.

As shown, acetaminophen, a widely used analgesic drug, is rapidly metabolized to a hepatotoxic N-acetyl-p-quinone intermediate by a number of cytochrome P450 enzymes. Acetaminophen’s analgesic and antipyretic properties are due to the inhibition of cyclooxygenase enzymes involved in prostaglandin synthesis. Limited amounts of acetaminophen may be safely ingested, but larger amounts fully deplete the stores of glutathione and can lead to liver failure or even death.

Warnings about this are printed on every package of acetaminophen.

By Manfred E. Wolff
Laguna Beach, Calif

Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society

Leave A Comment

*Required to comment