Volume 90 Issue 19 | p. 29 | Concentrates
Issue Date: May 7, 2012

Amyloid-β Gets Toxic Helping Hand

Alzheimer’s peptide needs another pyroglutamate-modified peptide to misfold and eventually cause nerve cell death
Department: Science & Technology
News Channels: Biological SCENE
Keywords: Alzheimer’s, amyloid, tau protein, neuroscience, neurodegeneration, oligomers

Amyloid-β, the peptide that misfolds and then forms plaques in the brains of Alzhei­mer’s patients, likely misfolds with help from a less prevalent, modified version of itself, according to a report in Nature (DOI: 10.1038/nature11060). Scientists have suspected that forms of amyloid-β modified with an amino-terminal pyroglutamate trigger unmodified amyloid to misfold, but they haven’t been sure of the mechanism for this interaction. On the basis . . .

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