Volume 90 Issue 19 | p. 29 | Concentrates
Issue Date: May 7, 2012

Resveratrol Rides Again

Study attempts to settle sirtuin spat with a first look at knockout mice
Department: Science & Technology
Keywords: Knockout mouse, resveratrol, sirtuins, calorie restriction, aging

Ever since scientists learned about the red wine compound resveratrol’s reputed health and antiaging effects, they’ve been debating how the molecule works. The hubbub hinges on whether resveratrol targets sirtuin enzymes, the idea behind the biotech firm Sirtris Pharmaceuticals, which Glaxo­SmithKline purchased for $720 million in 2008. The latest salvo comes from Harvard Medical School’s David A. Sinclair, a Sirtris founder, who for the first time . . .

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