ADVERTISEMENT
2 /3 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Physical Chemistry

Binding Study Could Aid Search For Better Selectin Blockers

Thermodynamics explain how carbohydrate ligand binds to selectin protein associated with inflammation-related diseases

by Stu Borman
July 23, 2012 | APPEARED IN VOLUME 90, ISSUE 30

A study that explains how the carbo­hydrate sialyl Lewisx binds to the protein E-selectin in blood capillaries could lead to improved drugs for inflammatory conditions. Selectin proteins on surfaces of endothelial cells in blood capillaries play a key role in inflammation-related diseases such as rheumatoid arthritis and psoriasis. Selectin blockers that might alleviate such conditions are being sought, but finding druglike agents that bind tightly to selectins, as the natural ligand sialyl Lewisx does, has proven difficult. To better understand the driving force of the sialyl Lewisx/E-selectin interaction, Beat Ernst and coworkers at the University of Basel studied its detailed thermodynamics (Angew. Chem. Int. Ed., DOI: 10.1002/anie.201202555). They found that an array of directed hydrogen bonds on sialyl Lewisx enables it to selectively bind E-selectin. Sialyl Lewisx acts as what the team calls a “preorganized water oligomer” on a scaffold, unexpectedly making the binding interaction largely entropy-driven. The entropy of the interaction is increased, favoring complex formation, the researchers say, because ligand binding displaces a large number of water molecules from the binding interface to bulk water. These details could help refine efforts to design new selectin-blocking agents.

X

Article:

This article has been sent to the following recipient:

Leave A Comment

*Required to comment