Volume 90 Issue 6 | p. 31 | Concentrates
Issue Date: February 6, 2012

DNA Nanostructure Controls Transcription

Opening of tubular nanostructure exposes DNA template, thereby increasing gene transcription
Department: Science & Technology
News Channels: Biological SCENE
Keywords: DNA, transcription, nanotechnology

Japanese scientists have designed a DNA nanostructure that mechanically controls gene transcription (J. Am. Chem. Soc., DOI: 10.1021/ja2074856). Hiroshi Sugiyama, Masayuki Endo, and coworkers at Kyoto University attached a tubular DNA nanostructure to a double-stranded DNA template containing a promoter region that is enclosed in the tube. The tube also has single-stranded DNA called toehold strands. When complementary DNA binds . . .

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