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GlaxoSmithKline will close the Cambridge, Mass., labs of Sirtris, a biotech firm it acquired in 2008 for $720 million. The labs employ about 60 people, some of whom may relocate to GSK labs in the Philadelphia area. Sirtris is developing sirtuins, compounds thought to activate a biological pathway linked to antiaging effects. Resveratrol, a component of red wine, was the first sirtuin it explored, but the company stopped clinical trials after some patients developed kidney failure. A GSK spokeswoman says Sirtris continues to pursue next-generation sirtuins and that the move to GSK labs will take the effort to the next phase.
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