Iron Makes RNA Catalyze An Additional Chemical Reaction | Chemical & Engineering News
Volume 91 Issue 20 | p. 31 | Concentrates
Issue Date: May 20, 2013 | Web Date: May 22, 2013

Iron Makes RNA Catalyze An Additional Chemical Reaction

Replicating conditions on ancient Earth adds a new twist to RNA’s possible role in the origin of life
Department: Science & Technology
News Channels: Biological SCENE, Nano SCENE, Materials SCENE
Keywords: Origin of life, RNA World, catalysis, iron, redox, magnesium, electron transfer, DNA

Before photosynthesis emerged and filled the atmosphere with oxygen, Earth was essentially an oxygen-free zone, teeming with iron in its soluble 2+ form. Under those conditions, researchers report, ribonucleic acid could have been capable of even more feats than it is today (Nat. Chem. 2013, DOI: 10.1038/nchem.1649). RNA needs cations to fold properly, to catalyze chemical reactions, and to bind to other molecules. In most of modern biology, it uses magnesium cations. To examine what RNA would be like under prephotosynthetic conditions, Loren D. Williams and colleagues at Georgia Institute of Technology replaced RNA’s magnesium with iron while excluding oxygen. Sure enough, some of their RNA sequences became capable of catalyzing single-electron transfer reactions. This type of reduction reaction hasn’t been attributed to RNA before. The authors, who are part of the NASA Astrobiology Institute Center for Ribosomal Origins & Evolution, say their work implies that under these ancient conditions, RNA could have catalyzed the formation of DNA building blocks.

 
Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society

Leave A Comment

*Required to comment