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Two Swiss firms, Roche and Polyphor, have signed an agreement to develop Polyphor’s investigational macrocycle antibiotic to treat hospital-acquired bacterial infections caused by Pseudomonas aeruginosa. Polyphor discovers macrocyclic molecules that kill bacteria by modulating protein-protein interactions. Roche will pay Polyphor $38 million and may make future milestone payments. Polyphor will retain the option to copromote an inhaled formulation of the drug, called POL7080, in Europe.
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