Issue Date: March 24, 2014
Dynamics Determine Enzyme Selectivity
When chemists—or enzymes—try to create only one of a few possible products of a reaction, their strategy typically involves stabilizing the transition state that leads to the desired compound. In some cases, however, the route down an energy surface from a single transition state forks and forks again, leading to multiple products with no intermediate stops along the way.
That’s the case explored in a recent investigation of the biosynthesis of the tricyclic diterpene miltiradiene, . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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