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March 24, 2014 Cover

Volume 92, Issue 12

Human genetic studies point drugmakers to a specific sodium channel target for painkillers

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Volume 92 | Issue 12

All Issues

Changing The Channel

Human genetic studies point drugmakers to a specific sodium channel target for painkillers

  • Process Chemistry: Recasting Regulatory Strategies To Enable Green Chemistry

  • Restructuring For Real In Japan

    Pressured by high costs and a shrinking home market, producers are getting serious about slashing unprofitable businesses

  • Dynamics Determine Enzyme Selectivity

    Biosynthetic protein may steer a reaction after the transition state to home in on a single natural product

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Synthesis

Taking Cues From Nature En Route To Paclitaxel

ACS Meeting News: Synthesis of an intermediate along the way to the cancer drug opens avenues to novel analogs

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