Volume 92 Issue 16 | p. 31 | Concentrates
Issue Date: April 21, 2014

Kicking Enzymatic Aspartame Process Into Higher Gear

Enzyme-substrate structures reveal mechanism of key aspartame production reaction
Department: Science & Technology
News Channels: Biological SCENE
Keywords: thermolysin, aspartame, X-ray crystallography, enzyme mechanisms

The mechanism of an industrially important but sluggish protease-catalyzed reaction has been determined in a study that also suggests how it could be improved (ACS Med. Chem. Lett. 2014, DOI: 10.1021/ml500101z). The research also points the way toward improving other industrially promising protease reactions, which often have poor substrate-binding affinities and excessive reaction times. About 10% of the artificial sweetener aspartame produced worldwide each year . . .

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