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Pharmaceuticals

Celgene Pays Big For Antisense Drug

by Michael McCoy
April 28, 2014 | A version of this story appeared in Volume 92, Issue 17
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Celgene has agreed to pay $710 million to Ireland’s Nogra Pharma to license GED-0301, an oral antisense DNA oligonucleotide being developed for the treatment of Crohn’s disease. The drug works by shutting down messenger RNA that encodes for a protein, Smad7, involved in inflammation. On the basis of the results of a Phase II clinical trial, Celgene plans to initiate a Phase III program by the end of the year. If the drug is approved and successful, milestone payments to Nogra could reach $1.8 billion.

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