Volume 92 Issue 20 | p. 6 | News of The Week
Issue Date: May 19, 2014

NMR-EPR Combo Yields RNA-Protein Structure

Spectroscopy: Approach illuminates how translation activator works
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: noncoding RNA, small RNA, translation, protein sponge

A new technique that combines nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy has enabled researchers to determine the structure of a noncoding RNA bound to its target proteins. The structure helps explain how the RNA activates translation in bacteria by soaking up repressor proteins like a sponge.

Many important macromolecules, particularly those involving RNA, are structurally organized but also very floppy. Such extremely flexible macromolecules can be difficult to structurally characterize. The . . .

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