Volume 92 Issue 22 | p. 6 | News of The Week
Issue Date: June 2, 2014

Antibody Stifles Pain And Itch

Drug Discovery: Therapeutic targets single ion channel, dampens two sensations in mice
Department: Science & Technology
News Channels: Biological SCENE
Keywords: itch, pain, ion channel, voltage-gated sodium ion channel, drug discovery, antibody, analgesic, painkiller

An antibody developed by a research team at Duke University Medical Center not only suppresses the agony of pain, it also quells the irritation of itch in laboratory mice (Cell 2014, DOI: 10.1016/j.cell.2014.03.064). The two-for-one treatment works its magic by binding to a voltage-gated ion channel, dubbed Nav1.7, that scientists previously thought is responsible only for pain sensing.

One . . .

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