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Business

Two Pacts Target Oligonucleotides

by Michael McCoy
November 24, 2014 | A version of this story appeared in Volume 92, Issue 47
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Johnson & Johnson’s Janssen Biotech unit and the biotech firm Geron are joining to develop Geron’s imetelstat, a modified oligonucleotide in early-phase development as an oncology treatment. Janssen will pay Geron $35 million up front and up to $900 million in milestone payments. Separately, AstraZeneca and Isis Pharmaceuticals are forming an alliance to discover new delivery methods for antisense oligonucleotides. The partners intend to build on Isis’s ligand conjugation antisense technology, which they say lowers the dose needed for liver targets by about 10-fold.

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