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Merck & Co. has signed clinical research pacts with three rival companies to evaluate combinations of their drugs with MK-3475, a Merck antibody in development as a cancer immunotherapy. Merck will study MK-3475 in combination with Pfizer’s small-molecule kinase inhibitor Inlyta. The firm will investigate a combination of MK-3475 with Incyte’s investigational immunotherapy INCB24360. And Merck will test its drug with talimogene laherparepvec, an Amgen drug now in development. FDA dubbed MK-3475 a breakthrough therapy last year.
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