Volume 93 Issue 14 | p. 9 | News of The Week
Issue Date: April 6, 2015

α/β-Peptides Could Offer Low-Cost Alternative To Antibody Drugs

Drug Design: Researchers mix natural and nonnatural amino acids to make peptides that target large proteins
Department: Science & Technology
News Channels: Biological SCENE
Keywords: α/β-peptides, β-amino acids, VEGF, cancer, Z-domain

A peptide scaffold made partly of nonnatural β-amino acids could serve as a versatile source of potential drugs that bind large proteins such as the anticancer target VEGF, researchers report. The nonnatural peptides offer a possibly advantageous alternative to antibody-based agents that target large proteins because the peptides are easier to make and may last longer in the body.

To modulate the activity of proteins such as VEGF, drugmakers must block their interactions with other . . .

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