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Pharmaceuticals

Amphotericin B Analogs Boast Lower Toxicity

Drug Discovery: Drugs based on new amphotericin B derivatives could have reduced side effects

by Stu Borman
June 4, 2015 | APPEARED IN VOLUME 93, ISSUE 23

CLARIFICATION: This story was updated on June 5, 2015, to include a comment from an outside expert.

The natural product amphotericin B is an approved medication for treating some fungal infections, and fungi haven’t developed resistance to it. But the drug causes kidney damage, convulsions, heart failure, and other serious side effects. Researchers have now tweaked its molecular structure to create two versions that are much less toxic; are no more prone to resistance; and, according to the chemists, are readily synthesized and therefore amenable to industrial-scale production.

09323-notw3-structure-690.jpg
Two analogs, including the one shown here, differ from amphotericin B by replacement of a carboxyl group by a urea moiety (red).

Martin D. Burke of the University of Illinois, Urbana-Champaign; Susan Lindquist of Whitehead Institute for Biomedical Research, in Cambridge, Mass.; and coworkers developed the agents and tested them in mice with a Candida yeast infection (Nat. Chem. Biol. 2015, DOI: 10.1038/nchembio.1821). Revolution Medicines, in Redwood City, Calif., cofounded by Burke, has licensed them exclusively for antifungal drug development.

Amphotericin B attacks fungi by binding the fungal sterol ergosterol. But it also binds cholesterol in people, leading to its side effects. The researchers modified amphotericin B’s structure to bind ergosterol but not cholesterol. Fungi still don’t develop resistance to the new agents, and the compounds can be synthesized from the natural product in three steps at up to 25% yield.

Erick M. Carreira of the Swiss Federal Institute of Technology (ETH), Zurich, says his group and others have developed similar amphotericin B derivatives that have antifungal activity and diminished toxicity as good as the new analogs. Burke says his team’s analogs demonstrated a greater range of safe doses, compared with those previous compounds, but Carreira replies that data reported in the new study are insufficient to substantiate that claim.

Fungal disease expert David W. Denning of the University of Manchester, in England, cautions that the new agents were tested against only one fungal infection and would need to be administered at doses too high to be useful. He adds that the real need is for oral agents, whereas the new agents, as is the case with amphotericin B, would have to be injected. Nevertheless, he calls the analogs’ low toxicity “remarkable,” their antifungal activity “impressive,” and the lack of fungal resistance against them “important.”

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Comments
R. D. G. Cooper (June 10, 2015 6:06 PM)
These researchers have resurrected the last ditch antifungal drug, used when nothing else would work in spite of severe organ damage, a true Hobson's choice for the clinician. It had always been considered as a very difficult molecule to work on with little chance of alleviating the toxicity. They are to be congratulated on this achievement and lets all hope that the clinical results will be as formidable.

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