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The cells of microbes and their mammalian hosts are decorated with glycans that can be read by carbohydrate-binding proteins known as lectins. By using microarrays with synthetic and microbial glycans, Laura L. Kiessling of the University of Wisconsin, Madison, and coworkers show that one such protein, human intelectin-1, exclusively binds microbial glycans instead of mammalian glycans (Nat. Struct. Mol. Biol. 2015, DOI: 10.1038/nsmb.3053). In particular, intelectin-1 binds the sugar β-linked
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