Volume 93 Issue 37 | pp. 25-26 | Concentrates
Issue Date: September 21, 2015

Designed Enzyme On Par With The Natives

Enzymology: Enhancing electron transfer by modified myoglobin gives a synthetic enzyme bio-like activity
Department: Science & Technology
News Channels: Biological SCENE, JACS In C&EN, Organic SCENE
Keywords: enzymes, protein engineering, myoglobin, cytochrome oxidases

Designing functional enzymes has been a dream of chemists, but most synthetic enzymes have activity that falls far short of those put forward by Mother Nature. Researchers have now achieved a rare success in the field by converting a nonenzymatic metalloprotein into a designed metalloenzyme with cytochrome oxidase activity that nearly matches that of native oxidases (J. Am. Chem. Soc. 2015, DOI: 10.1021/jacs.5b07119). . . .

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