Volume 93 Issue 38 | p. 35 | Concentrates
Issue Date: September 28, 2015

Multi C–H Functionalizations

Organic Chemistry: Four C–H functionalization reactions in a row promote total synthesis of the natural product (–)-incarviatone A
Department: Science & Technology
News Channels: JACS In C&EN, Organic SCENE
Keywords: incarviatone A, natural product, total synthesis, C–H activation, C–H functionalization

Developing C–H functionalization reactions is a major focus of organic chemistry research. But using different C–H functionalizations sequentially to streamline complex syntheses remains challenging. Houhua Li and Xiaoguang Lei of Peking University and the National Institute of Biological Sciences, both in Beijing, and coworkers have now used an unprecedented four C–H functionalization reactions as part of a 14-step first enantioselective total synthesis of the natural product (–)-incarviatone A (J. Am. Chem. Soc. . . .

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