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Business
Genentech Teams With Arvinas
by Lisa M. Jarvis
October 12, 2015
| A version of this story appeared in
Volume 93, Issue 40
Genentech and Arvinas will work together to develop small molecules that invoke protein degradation and disposal. The pact, which includes an undisclosed up-front payment, could be worth up to $300 million in milestones for privately held Arvinas, which was spun out of the labs of Yale University chemist Craig Crews. Whereas conventional drugs work by blocking the activity of a protein, Arvinas is using bifunctional small molecules called proteolysis-targeting chimeras to “tag” certain proteins for breakdown by the ubiquitin-proteasome system.
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