ADVERTISEMENT
2 /3 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Biological Chemistry

Antidepressants Help Cellular Pathways That Decrease DNA Methylation

Neuroscience: Findings could lead to blood test that identifies most effective drug for a patient

by Michael Torrice
November 30, 2015 | APPEARED IN VOLUME 93, ISSUE 47

Gene expression in cells changes as diseases progress, even in psychiatric disorders such as depression. For example, compared with healthy people, some patients with depression have altered patterns of DNA methylation, a chemical modification that typically reduces gene expression. Now researchers report one way in which antidepressants can manipulate these epigenetic pathways. Their findings suggest a possible blood test to determine whether a certain antidepressant will be effective for a given patient. Based on tests conducted on mice and cultured cells, Theo Rein of the Max Planck Institute of Psychiatry and colleagues studied how the antidepressant paroxetine reduces the activity of an enzyme that adds methyl groups to DNA. They found that the drug works though a chaperone protein that prevents the enzyme from becoming phosphorylated, a key step in the enzyme’s activation. When the researchers added paroxetine to blood cells from patients with depression, they found that the decrease in enzyme phosphorylation inversely correlated with how well the patient responded to antidepressant treatment: Larger drops in phosphorylation on average led to a greater improvement in depression symptoms (Sci. Signaling 2015, DOI: 10.1126/scisignal.aac7695).

X

Article:

This article has been sent to the following recipient:

Leave A Comment

*Required to comment