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Cancer Drugs Were Most Sought After In 2015

Immuno-Oncology: Driven by data, deal-making was hot last year

by Lisa M. Jarvis
December 7, 2015 | APPEARED IN VOLUME 93, ISSUE 48

Excitement over immuno-oncology treatments reached manic levels in 2015. As more data emerged to support the notion that harnessing the immune system is an effective way to battle cancer, companies jockeyed for assets to add to their portfolios. Each month seemed to bring another sizable deal, company launch, or notable clinical development.

One of the year’s most important developments came in May during the American Society of Clinical Oncology’s annual meeting. Amid a crowded auditorium in Chicago, Memorial Sloan Kettering Cancer Center oncologist Jedd Wolchok showed that combining Bristol-Myers Squibb’s CTLA4 inhibitor Yervoy and its PD-1 inhibitor Opdivo was more effective in treating metastatic melanoma than using either therapy alone.

That result underscores a key theme in cancer immunotherapy, says Paul D. Rennert, head of the consulting firm SugarCone Biotech. The large trial provided the first substantial evidence that, as researchers suspected, cancer immunotherapies work best with partners.

And the best partners will be “checkpoint inhibitors,” antibodies that take the brakes off the immune system. “If there’s going to be combinations, the PD-1 inhibitors will be the backbone of the combination—it’ll be a PD-1 inhibitor plus something else,” says Colin White, an analyst at Datamonitor Healthcare. “What’s not well understood at this time is what that ‘something else’ will be.”

To that end, companies spent the year broadening their portfolios to ensure they had access to a backbone therapy plus complementary molecules.

Sanofi, for example, committed $1.8 billion to an immuno-oncology pact with Regeneron through which it gained both a PD-1 inhibitor and antibodies against several other immune checkpoint targets. Celgene shelled out $450 million to participate in development of AstraZeneca’s PD-L1 inhibitor MEDI4736.

Other prominent deals include Bristol-Myers Squibb’s $1.25 billion buyout of Flexus Biosciences, a biotech firm with small molecules that block IDO, an enzyme that helps cancer cells evade immune surveillance.

But even as companies compete for the best agents to combine, researchers acknowledge a steep learning curve in figuring out how to pair them safely. The Yervoy-Opdivo combination carried side effects that were severe enough for more than one-third of patients in that arm of the trial to discontinue treatment.

BACKBONE
09348-cover8-immunocxd-690.jpg
Credit: BMS
BMS’s Opdivo, the ribbon structure shown here bound to PD1 (space-filling), will be a key partner in many immuno-oncology combinations.

And Yervoy and Opdivo are expensive. Although the list price of $256,000 per year for the combination therapy, which the Food & Drug Administration approved in October, is lower than the sum of the individual drugs, the question of how much immunotherapies should cost became more acute this year.

Cost became a flash point for another set of attention-grabbing immuno-oncology agents: cellular therapies. Chimeric antigen receptor T-cell (CART) therapies, made by reengineering a patient’s own T cells to seek and destroy cancer cells, have elicited remarkable responses in some types of blood cancers and prompted another batch of partnerships.

But because they are individualized, CARTs, if approved, are expected to be extremely expensive. Companies, insurers, and other stakeholders are already contemplating new mechanisms to pay for them.

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