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Roche will pay Blueprint Medicines $45 million up front as part of a broad pact to develop small-molecule cancer immunotherapies. Roche has the option to license up to five small molecules targeting immunokinases, proteins that play a role in regulating immune cells’ response. Blueprint is tasked with early development of the drug candidates, and Roche can buy into each program after Phase I data are available. Blueprint could secure close to $1 billion more in option and milestone fees if Roche licenses all five programs.
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