Issue Date: April 18, 2016 | Web Date: April 14, 2016
New radical route to chiral quaternary carbons reported
Many natural products, pharmaceuticals, and other biologically active molecules feature chiral carbon atoms attached to four other carbons. Chemists can synthesize these quaternary stereocenters using organometallic reagents that add carbon groups to conjugated carbonyl compounds. These reagents, however, are expensive and hard to generate, can cause problematic side reactions, and don’t always work well at crowded carbon centers.
Now researchers report a new radical route to quaternary carbon stereocenters, offering a possibly easier way to . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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