Ketamine metabolite could inspire fast-acting antidepressants | May 5, 2016 Issue - Vol. 94 Issue 19 | Chemical & Engineering News
Volume 94 Issue 19 | p. 5 | News of The Week
Issue Date: May 9, 2016 | Web Date: May 5, 2016

Ketamine metabolite could inspire fast-acting antidepressants

New findings indicate that hydroxynorketamine is essential for the drug’s activity in mice
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: neuroscience, antidepressants, ketamine, hydroxynorketamine, GLYX-13, rapastinel

Ketamine offers psychiatrists something that conventional antidepressants lack: speed. Most patients take selective serotonin reuptake inhibitors such as Prozac or Zoloft for weeks to months before they feel any improvement. But a single dose of ketamine can act within hours.

Unfortunately, the compound, used for decades as an anesthetic, comes with some downsides, including the potential for abuse as a psychedelic . . .

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