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Analytical Chemistry

C&EN profiles ICCAS, one of China’s leading chemistry institutes

By all measures, the Institute of Chemistry of the Chinese Academy of Sciences is a rising star

by Mitch Jacoby
October 10, 2016 | A version of this story appeared in Volume 94, Issue 40

This photo shows a researcher in battery testing lab.
Credit: Mitch Jacoby/C&EN
In this high-throughput testing facility, ICCAS’s Yu-Guo Guo puts row after row of Li-ion cells through charging cycles to evaluate custom-made battery materials.

When stating his ambitions for the Institute of Chemistry of the Chinese Academy of Sciences (ICCAS), its director, Deqing Zhang, doesn’t pull any punches. “We aim to become one of the top chemistry research institutions in the world,” he says.

ICCAS at a glance

Year founded: 1956

Number of faculty members and technical staff: 617

Number of faculty who are members of the Chinese Academy of Sciences: 12

2015 budget: 686 million CNY (~$103 million)

Number of students who graduated between 1978 and 2015: 5,310 (2,111 master’s degrees; 3,199 Ph.D. degrees)

Number of patents awarded since 2010: ~1,000

Number of non-Chinese patents in ICCAS portfolio: >100

Motivated and enthusiastic, Zhang is proud of the Beijing-based chemistry center’s accomplishments and confident about its abilities. “We have talented research teams and advanced facilities that can match—or eventually exceed—those of any first-class chemistry research institution.” Still, he’s also pragmatic and knows where things stand. “That’s our goal. But we’re not yet at that stage.”

One way to boost the institute’s standing in the greater chemistry community is to showcase its accomplishments on the international stage. ICCAS will get the chance to do some of that scientific show-and-tell later this month when it celebrates its 60th anniversary with a large contingent of chemists from China and abroad. ICCAS and the American Chemical Society are co-organizing an international conference, titled Innovation in Molecular Science. The meeting is expected to draw more than 200 scientists from across China, the rest of Asia, Europe, the U.S., and Canada.

Rubbing elbows with ICCAS scientists during a multiday symposium at a Beijing hotel is one way to learn about the institute’s history, goals, achievements, and people. Another way is to visit ICCAS directly, talk with directors and researchers, and tour its laboratories. That’s what this C&EN correspondent did.

Posed photo of six men.
Credit: Mitch Jacoby/C&EN
ICCAS’s directors include (sitting, left to right) Dujin Wang, Deqing Zhang, (standing, left to right) Yongjun Shi, Lanqun Mao, Renquan Huang, and Qinghua Fan.

The Chinese Academy of Sciences (CAS), China’s leading national scientific research and education network, established the Institute of Chemistry in 1956. As Zhang explains, ICCAS is a multidisciplinary organization dedicated to fundamental research in major areas of the chemical sciences. The institute’s goals are aimed at meeting the country’s critical national needs and strategic targets. ICCAS also actively seeks industrial collaborations for technology transfer and to turn laboratory innovations into commercial applications.

ICCAS scientists work at the frontiers of several modern, thriving areas of scientific research, such as molecular and nanosciences, organic and polymeric materials, chemical biology, energy sciences, and green chemistry. Their research is anchored by “core competencies” in traditional areas, including physical, analytical, polymer, organic, and inorganic chemistry.

Prolific publisher
ICCAS scientists publish broadly and frequently throughout the chemical sciences.
Source: ICCAS
A bar chart showing an upward trend in the amount of papers ICCAS has published in peer-reviewed journals from 2005-2015.
ICCAS scientists publish broadly and frequently throughout the chemical sciences.
Source: ICCAS

As might be expected from a large bureaucratic country, much of China’s scientific research is organized according to a hierarchical laboratory system. For example, the academy supports many so-called CAS Key Laboratories. CAS awards that prestigious designation—and the ample level of funding that goes with it—to teams of investigators with an impressive research track record in a select area.

ICCAS is home to eight such labs including the CAS Key Laboratory of Organic Solids, the CAS Key Laboratory of Green Printing, the CAS Key Laboratory of Analytical Chemistry for Living Biosystems, and the CAS Key Laboratory of Engineering Plastics.

A step up from those labs—in terms of prestige and financial support—are the so-called State Key Laboratories. ICCAS is home to three such labs, including the State Key Laboratory of Polymer Physics & Chemistry, the State Key Laboratory of Molecular Dynamics, and the State Key Laboratory for Structural Chemistry of Unstable & Stable Species.

When visiting the facilities and discussing the scientific posters that adorn the hallways, it becomes clear that the institute actively pursues a broad range of topics throughout the chemical sciences.

Credit: Mitch Jacoby/C&EN
A suite of surface science instruments supports ICCAS research on organic semiconductors and other materials.
Photo of a man examining surface science vacuum equipment.
Credit: Mitch Jacoby/C&EN
A suite of surface science instruments supports ICCAS research on organic semiconductors and other materials.

Yanlin Song, a chemistry professor who heads the Laboratory of Green Printing, enthusiastically describes his team’s environmentally beneficial innovations in printing technology. He explains that traditional methods widely used in China and elsewhere for newsprint and other applications are based on photosensitization processes for producing the plates that transfer an image to paper, plastic, or other print medium.

Credit: Mitch Jacoby/C&EN
In this ICCAS lab, researchers use a custom-made mass spectrometer to analyze nanoparticles.
Photo of 2 men in a lab wearing laser goggles.
Credit: Mitch Jacoby/C&EN
In this ICCAS lab, researchers use a custom-made mass spectrometer to analyze nanoparticles.

Song’s lab developed a new platemaking method that is based on ink-jetting customized hydrophobic nanomaterials onto superhydrophilic plates. It bypasses photosensitization and the associated exposing, developing, and washing steps. Those steps consume large quantities of silver, aluminum, and organic compounds and generate much waste. As such, the new method is nonpolluting, low-cost, and relatively simple.

A key feature of the green printing method, which has been commercialized in China, is tuning materials properties, such as surface energy and hydrophobicity, to control ink spreading in newspapers, magazines, and other printed products. Just recently, Song’s team used a similar strategy to control nanoparticle ink spreading in transparent, flexible electronic circuits. Such circuits are expected to underpin wearable displays and other flexible devices.

In particular, the lab made transparent, multilayer circuits with exceptionally fine (1.6-μm diameter) silver wires that remained conductive after thousands of bending cycles (Adv. Mater. 2016, DOI: 10.1002/adma.201503682). To do so, researchers tailored the viscosity of a polydimethylsiloxane (PDMS) precursor solution and the density of a suspension of silver nanoparticles so that, when the team ink-jet printed the particles, the silver sank into the PDMS film and coalesced, forming microscopic, embedded wires.

In the CAS Key Laboratory of Colloid, Interface & Chemical Thermodynamics, Buxing Han’s group is also working on green chemistry research. They have been developing methods for making commodity chemicals from the greenhouse gas CO2.

In one recent study, Han’s group was searching for ways to convert CO2 to methanol, an attractive starting material for making chemicals and fuels. Electroreduction is seen as a promising conversion route, but the electrocatalysts studied so far exhibit low efficiency and poor selectivity.

Searching for better catalysts, Han’s group prepared nanosheets of various bimetallic chalcogenides on carbon paper and showed that molybdenum-bismuth-based chalcogenides outperform other catalytic electrodes previously studied for CO2-to-methanol conversion (Angew. Chem. Int. Ed. 2016, DOI: 10.1002/anie.201603034).

In another study, the team demonstrated that CO2, methanol, and hydrogen can react in the presence of a ruthenium-rhodium catalyst and 1,3-dimethyl-2-imidazolidinone solvent to produce acetic acid. Acetic acid is used on a bulk scale and is produced commercially via methanol carbonylation using CO, which is produced from fossil fuels (Nat. Commun. 2016, DOI: 10.1038/ncomms11481).

Other ICCAS teams work at the interface of biology and chemistry. For example, Lanqun Mao, one of ICCAS’s deputy directors, develops electrochemical methods to selectively detect ascorbate and other neurochemicals in living mammalian brains. Mao recently published a review covering his group’s and the field’s latest advances (Electroanalysis 2016, DOI: 10.1002/elan.201500376).

Silver circuits
This schematic shows the method used to make flexible, transparent circuits, and a gloved hand with an example circuit.
Credit: Adv. Mater.
A polydimethylsiloxane (PDMS) film on polyethylene terephthalate (PET) envelops silver nanoparticles, which coalesce and form ultrafine, embedded wires. Researchers used the method to make multilayer, transparent, flexible circuits (patch on hand).

Still other teams work to develop novel materials for a great variety of applications, including solar cells, energy storage, molecular recognition, optoelectronics, organic field-effect transistors, and data storage.

The smattering of research discussed during a one-day visit to ICCAS barely dives into the quickly growing pile of papers its researchers are publishing these days. In 2005, the institute was proud to have landed nearly 35 papers in leading journals such as Science, Nature, Angewandte Chemie International Edition, and the Journal of the American Chemical Society. The total number of papers published that year by ICCAS scientists was 530. By 2015, those numbers had climbed to 115 papers in premier journals and 709 in total.

ICCAS’s directors and faculty members aren’t the only ones who hold the Beijing institute in high esteem. “ICCAS is a top research institute and highly regarded throughout the scientific community,” asserts Ben Zhong Tang, a chemistry professor at the Hong Kong University of Science & Technology. Tang, who is also a member of CAS, notes that ICCAS carries out high-quality research and has published many papers with high impact. “I would rank it an excellent research center. And I believe many of my colleagues would agree with my ranking.”

Tang adds that ICCAS Ph.D.s and postdocs seeking appointments at other Chinese research centers are well-received. “I would not be surprised to see some ICCAS Ph.D.s and postdocs grow to become research leaders in China and even throughout the world.”

Credit: Mitch Jacoby/C&EN
ICCAS students have ready access to advanced NMR spectrometers and assistance from Ningning Wu and other skilled lab technicians.
Photo of a woman in a lab preparing sample for NMR analysis.
Credit: Mitch Jacoby/C&EN
ICCAS students have ready access to advanced NMR spectrometers and assistance from Ningning Wu and other skilled lab technicians.

That sentiment is echoed by prominent non-Chinese chemists, such as the University of Utah’s Peter J. Stang. “ICCAS is one of the very best chemistry institutes in China,” says Stang, who led an international committee that evaluated ICCAS in 2013.

In support of his assessment, Stang points out that ICCAS has been shaped by some of China’s most illustrious chemists, including CAS member and President Chunli Bai, who formerly served as an ICCAS deputy director. Stang also notes that ICCAS has “excellent research facilities” and publishes regularly in leading journals.

Stang, who is editor-in-chief of JACS, notes that, in the early 1990s, China as a whole published very few papers in JACS. As of two years ago, he says, China has grown to become the largest contributor outside of North America of JACS papers. And ICCAS is regularly one of the largest contributors of those papers.

By all measures, ICCAS is a prominent chemistry center with an excellent reputation. The aspirations of Zhang and his colleagues to boost the institute’s standing to world-class don’t seem extreme or unrealistic as ICCAS’s star is rising quickly. They have every reason to be confident and proud. 

CORRECTION: On October 10, 2016, the At A Glance box in this story was updated to correctly reflect ICCAS’s 2015 budget. It was 686 million CNY, not 686 CNY.


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