Volume 94 Issue 42 | p. 8 | News of The Week
Issue Date: October 24, 2016 | Web Date: October 19, 2016

One-step method determines reaction products’ yield, enantiomeric excess, and configuration

Technique accelerates evaluation of amine-containing chiral compounds
Department: Science & Technology
News Channels: Analytical SCENE, JACS In C&EN, Organic SCENE
Keywords: analytical chemistry, chiral, complexation, amine

A new technique makes it much easier and cheaper to determine key characteristics of amine-containing chiral compounds synthesized individually or in parallel. The technique, which measures product yield, enantiomeric excess (ee), and absolute configuration in one step, could find widespread use in organic chemistry laboratories, including in drug discovery.

Chemists typically determine product yield by isolating synthesized compounds and weighing them. They generally measure ee by analyzing reaction products with chiral high-performance liquid chromatography and . . .

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