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Group Blames Pesticide For Microcephaly

Pesticides: Experts debunk connection between pyriproxyfen and epidemic among newborns

by Marc S. Reisch
February 17, 2016 | A version of this story appeared in Volume 94, Issue 8

Mosquito larvae thrive in water in a laboratory beaker.
Credit: Tom Campbell/Purdue University
Mosquito larvae develop in water before emerging as adults.Mosquito larvae develop in water before emerging as adults.

An Argentinian physicians group claims that a larvicide, not Zika virus, is responsible for an outbreak of infants born with small heads in Brazil. While some local governments in Brazil have stopped using the larvicide, pyriproxyfen, government authorities and scientific experts contend that it is safe.

Pyriproxyfen is used to treat drinking water, where it kills off the larvae of mosquitoes, including those responsible for transmitting Zika virus. Over the past year, Brazilian authorities have counted more than 4,000 cases of microcephaly, as the affliction in newborns is known, in areas where Zika virus is now widespread.

A report from Physicians in the Crop-Sprayed Villages insists that marketing efforts by the chemical’s maker, Sumitomo Chemical, and government indifference to the mostly poor population affected by microcephaly are responsible for the tragedy.

But Brazil’s Ministry of Health says that “no epidemiological studies show the association between use of pyriproxyfen and microcephaly.” On the other hand, tests of blood, tissue, and amniotic fluid from affected infants suggest a relationship between Zika and microcephaly, according to the ministry. Some localities that do not use pyriproxyfen also have reported microcephaly cases, the ministry adds.

Sumitomo asserts that the chemical, which it discovered in 1984, is safe and that “concerns related to microcephaly are totally unfounded.” The product is approved in 40 countries and recommended by the World Health Organization as safe for use in drinking water, Sumitomo says.

Pyriproxyfen works by interfering with mosquitoes’ growth hormones “from hatching, to larvae, to pupae,” explains Ian Musgrave, a pharmacology lecturer at the University of Adelaide. The hormonal pathway of the growth regulator, so effective against mosquitoes, “does not exist in organisms with backbones, such as humans,” he says. “Pyriproxyfen has very low toxicity in mammals as a result.”

Some scientists wonder whether an unknown agent is responsible for the microcephaly. “Perhaps they are getting a new chemical that forms on reaction of pyriproxyfen with whatever reagent they use for water purification,” suggests Susan Kegley, CEO of the consulting firm Pesticide Research Institute. “There is certainly more than one possibility.”



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