ADVERTISEMENT
2 /3 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Biological Chemistry

Peptide-containing nanofibers keep bacterial infections at bay

Quorum-sensing inhibitors incorporated into electrospun nanofibers could prevent bacterial infections

by Wudan Yan, special to C&EN
March 6, 2017 | APPEARED IN VOLUME 95, ISSUE 10

[+]Enlarge
Credit: ACS Infect. Dis.
Electrospun fibers containing a peptide that blocks bacterial quorum sensing prevent Staphylococcus aureus from activating its infectious pathways.
Credit: ACS Infect. Dis.
Electrospun fibers containing a peptide that blocks bacterial quorum sensing prevent Staphylococcus aureus from activating its infectious pathways.
This peptide blocks quorum sensing in S. aureus.

Researchers have developed a new infection-blocking material made of peptide-containing nanofibers that works against antibiotic-resistant bacteria and could one day be incorporated into wound dressings (ACS Infect. Dis. 2017, DOI: 10.1021/acsinfec​dis.6b00173). The approach targets bacterial quorum sensing—a mode of chemical communication used by bacteria to detect other bacteria. When they sense that enough of their kind are present, they can mount an infectious attack. Chemist Helen E. Blackwell of the University of Wisconsin, Madison, has developed peptides to block this quorum-sensing pathway, thereby preventing cells from attacking their host. Together with David M. Lynn and other Wisconsin colleagues, Blackwell electrospun one of these peptides into poly(lactide-co-glycolide) nanofibers. The researchers tested nanofiber mats against normal and deadly antibiotic-resistant strains of Staphylococcus aureus. By using a strain of S. aureus engineered to carry fluorescent reporter genes, the scientists found that the fibers with quorum-sensing inhibitors were able to block the bacteriafrom successful quorum sensing for up to two weeks. Moreover, when cultured in petri dishes with red blood cells, the treated bacterial cells did not rupture the blood cells, whereas untreated cells did. The presence of ruptured cells indicates that bacteria are using quorum sensing to coordinate an infection.

X

Article:

This article has been sent to the following recipient:

Leave A Comment

*Required to comment