Volume 95 Issue 2 | p. 9 | Concentrates
Issue Date: January 9, 2017

Biocatalytic cofactor recycled efficiently

Process could reduce cost of making NADP+ by more than five orders of magnitude
Department: Science & Technology
News Channels: Organic SCENE, Biological SCENE
Keywords: biocatalysis, nicotinamide adenine dinucleotide phosphate, NADP+, enzymes, cofactor

Oxidoreductase enzymes are used extensively as biocatalysts for industrial and academic reactions, including pharmaceutical synthesis. But they almost exclusively require expensive cofactors such as NADP+, the oxidized form of the biological cofactor nicotinamide adenine dinucleotide phosphate. The reagent currently costs about $22,000 per mole. Enzymes that can recycle it from its reduced form, NADPH, have drawbacks that have limited their use, such as low activity, unwanted by-product generation, and short lifetimes. Guided by nature, which . . .

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