Modeling reduces nickel needed in catalytic reactions | Chemical & Engineering News
Volume 95 Issue 25 | p. 10 | Concentrates
Issue Date: June 19, 2017

Modeling reduces nickel needed in catalytic reactions

Technique adjusts reaction conditions to optimize catalyst use in cross-coupling esterifications
Department: Science & Technology
Keywords: catalysis, nickel, catalysts, cross-coupling, esterification, kinetic modeling

Nickel catalysts are much less expensive than precious metal catalysts, but the large amounts of nickel catalyst used in many catalytic cross-coupling reactions still discourage industrial adoption. Over roughly the past two years, the vast majority of newly reported nickel-catalyzed cross-coupling reactions required 5 to 20 mole % of nickel catalyst. Neil K. Garg of the University of California, Los Angeles, grad student Nicholas A. Weires, and colleague Daniel D. Caspi of AbbVie have now . . .

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