Slug mucus inspires possible surgical glue | July 31, 2017 Issue - Vol. 95 Issue 31 | Chemical & Engineering News
Volume 95 Issue 31 | p. 8 | News of The Week
Issue Date: July 31, 2017 | Web Date: July 27, 2017

Slug mucus inspires possible surgical glue

Material sticks more strongly to wet tissues than commercially available medical adhesives do
Department: Science & Technology
News Channels: Materials SCENE, Biological SCENE, Materials SCENE, Biological SCENE
Keywords: adhesives, surgical adhesive, wound repair, bioinspired materials
A slug-mucus-inspired adhesive sticks to a pig heart.
Credit: Science
A pig heart with a strip of green adhesive stuck to it.
A slug-mucus-inspired adhesive sticks to a pig heart.
Credit: Science

To help cling to leaves and other surfaces, some slugs secrete a sticky mucus. Engineers have used this slug secretion as inspiration to develop a synthetic adhesive that is significantly stronger than commercially available surgical glues (Science 2017, DOI: 10.1126/science.aah6362).

“It’s a really elegant and creative design to make tough adhesives that work in wet environments,” says Mark W. Grinstaff of Boston University, who was not involved in the work.

To close up wounds or surgical incisions, doctors sometimes reach for glues to hold tissues together. But sticking something to flesh can be tricky because biological tissues are wet and oddly shaped, and they move, says David J. Mooney of Harvard University.

Mooney and his colleagues came across a paper analyzing the material properties of mucus from a type of slug (Arion subfuscus). The sticky mucus has two components: polycations that help the mucus adhere to surfaces through electrostatic interactions and covalent bonding, and a tough matrix that absorbs and dissipates stress. This combination allows the slug to stick strongly to a surface by resisting forces—such as those from wind, rain, or the beak of a hungry bird—that could dislodge it.

To mimic this design, Mooney’s team created a stress-dissipating matrix from cross-linked polymers, polyacrylamide, and alginate. The researchers then coated the matrix with the polycation chitosan, which inserts itself into the matrix and produces an adhesive surface. “It’s an example of simple elegance,” how the team put together already available materials in a new way to solve a problem, says Jennifer Elisseeff, a biomedical engineer at Johns Hopkins University.

The researchers tested the adhesive on pig skin, liver, heart, and cartilage and found that it was stronger than both cyanoacrylate (superglue) and a surgical sealant called CoSeal. The experiment that most impressed Grinstaff was one involving a wound on a liver. “Getting the liver to seal and stop bleeding is currently a big clinical problem,” he says. “There are no good adhesives for that application today.”

Mooney’s team is testing the material further to optimize its properties and determine which medical applications it is suited for.

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