Volume 95 Issue 37 | p. 7 | News of The Week
Issue Date: September 18, 2017 | Web Date: September 14, 2017

Enzyme coordinates pericyclic reaction trifecta

LepI catalyzes three concerted rearrangements en route to the natural insecticide leporin C
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: Biochemistry, LepI, pericyclic, leporin

Pericyclic reactions, in which electrons move in concert to rearrange a molecule’s structure, are standard tools for synthetic chemists. But examples of such transformations in nature are fairly rare. Chemists have now identified an enzyme that catalyzes three pericyclic reactions in the biochemical pathway that produces the fungal natural product leporin C.

“This really opens up the idea that nature is able to affect reactions of much broader generality than we ever knew before,” says . . .

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