Volume 95 Issue 41 | p. 5 | News of The Week
Issue Date: October 16, 2017 | Web Date: October 12, 2017

Bryostatin advances: A shorter synthesis and an HIV takedown

29-step route promises to boost dwindling supply of bryostatin 1, while an analog kicks latent virus out of cells and kills it
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: Medicinal chemistry, bryostatin 1, bryolog

The marine natural product bryostatin 1 has shown promise as a treatment for cancer, Alzheimer’s disease, and HIV. But neither the compound nor its analogs have become approved drugs. One of the problems that has dogged bryostatin 1 is its scarce supply. Now, chemists at Stanford University led by Paul A. Wender have developed a shortened synthesis of bryostatin 1 . . .

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