Incyte, MacroGenics pen cancer deal | October 30, 2017 Issue - Vol. 95 Issue 43 | Chemical & Engineering News
Volume 95 Issue 43 | p. 11 | Concentrates
Issue Date: October 30, 2017

Incyte, MacroGenics pen cancer deal

Department: Business
Keywords: Oncology, Incyte, MarcoGenics, PD-1 inhibitor

Incyte will pay $150 million up front for global rights to MacroGenics’s MGA012, a PD-1 inhibitor in Phase I studies. MGA012 belongs to a class of cancer immunotherapies called checkpoint inhibitors, antibodies that take the brakes off the immune system so it can find and kill cancer cells. Incyte has a complementary drug, a small molecule that blocks the enzyme IDO1, being tested in combination with myriad competitors’ PD-1 inhibitors. The deal will give Incyte its own PD-1 inhibitor, albeit one that significantly trails competitors. Merck & Co. and Bristol-Myers Squibb both have PD-1 inhibitors on the market, and multiple companies have checkpoint inhibitors in mid- or late-stage clinical studies.

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