Peptides are designed to treat common infection | November 20, 2017 Issue - Vol. 95 Issue 46 | Chemical & Engineering News
Volume 95 Issue 46 | p. 9 | Concentrates
Issue Date: November 20, 2017

Designer peptides treat stomach pathogen

Agents could be alternatives to Helicobacter pylori triple therapy, which some bacteria resist
Department: Science & Technology
Keywords: Drug discovery, Helicobacter pylori, peptides, bacteria, resistance
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Under acidic conditions in the stomach, the new peptides, like the one shown, adopt a helical conformation (left) that kills bacteria like H. pylori. At normal physiological pH, they adopt a low-toxicity, random-coil conformation (right). Green balls are cationic amine groups, blue balls are anionic carboxylates, and black balls are neutral (protonated) carboxyl groups.
Credit: Adapted from PNAS
Figure shows the conformation change peptides undergo when moving from an acidic to a relatively neutral pH environment in the body.
 
Under acidic conditions in the stomach, the new peptides, like the one shown, adopt a helical conformation (left) that kills bacteria like H. pylori. At normal physiological pH, they adopt a low-toxicity, random-coil conformation (right). Green balls are cationic amine groups, blue balls are anionic carboxylates, and black balls are neutral (protonated) carboxyl groups.
Credit: Adapted from PNAS

About half the world’s population harbors Helicobacter pylori bacteria, which cause ulcers and cancer. Treatment of symptomatic patients usually involves triple therapy—two antibiotics and an acid reducer—but H. pylori resists some antibiotics. Treatment is also challenging because the pathogens reside in the stomach, where drugs need to tolerate high acidity. Jianjun Cheng and Lin-Feng Chen at the University of Illinois, Urbana-Champaign; Lichen Yin of Soochow University; and coworkers have now developed peptides that not only tolerate acidity but use it to activate their antibacterial activity (Proc. Natl. Acad. Sci. USA 2017, DOI: 10.1073/pnas.1710408114). At low pH, such as in the stomach, the orally administered peptides adopt a positively charged helical conformation that kills bacteria by disrupting their membranes. At the normal physiological pH of the intestines and bloodstream, the peptides transform into a random-coil conformation that doesn’t bind anything in particular very effectively, so they don’t kill “good” intestinal bacteria or hurt body cells. Liangfang Zhang of the University of California, San Diego, comments that in infected mice, the peptides have “impressive anti-H. pylori efficacy, equivalent to that of triple therapy.”

 
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