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Swiss drug giant Roche will expand its oncology pipeline with a $1.7 billion purchase of the San Diego-based drugmaker Ignyta. The deal is part of a growing trend to design cancer drugs that target tumors with particular genetic mutations, as opposed to a particular tissue. Ignyta’s lead cancer compound, entrectinib, is a small-molecule tyrosine kinase inhibitor. The firm has three other small-molecule programs for cancer, including one compound the company says could boost the innate immune response to tumors.
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