Enediyne biosynthetic intermediate found | March 19, 2018 Issue - Vol. 96 Issue 12 | Chemical & Engineering News
Volume 96 Issue 12 | p. 8 | Concentrates
Issue Date: March 19, 2018

Enediyne biosynthetic intermediate found

Iodoanthracene derivative is key intermediate en route to dynemicin A
Department: Science & Technology
Keywords: Natural products, enediynes, dynemicin A, biosythetic pathway, polyketide synthase

Since the first enediyne was discovered in 1985, scientists have been fascinated by this family of over a dozen natural products. The source of the compounds’ potent anticancer activity is their highly reactive enediyne unit, a double bond flanked by two triple bonds, which cleaves or cross-links genomic DNA by a unique molecular mechanism. Several enediynes are approved drugs or in clinical trials. Bacteria biosynthesize enediynes with multiple reactions that modify β-hydroxyhexaene, a common enediyne . . .

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