Issue Date: March 19, 2018
Enediyne biosynthetic intermediate found
Since the first enediyne was discovered in 1985, scientists have been fascinated by this family of over a dozen natural products. The source of the compounds’ potent anticancer activity is their highly reactive enediyne unit, a double bond flanked by two triple bonds, which cleaves or cross-links genomic DNA by a unique molecular mechanism. Several enediynes are approved drugs or in clinical trials. Bacteria biosynthesize enediynes with multiple reactions that modify β-hydroxyhexaene, a common enediyne . . .
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- Chemical & Engineering News
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