Issue Date: February 5, 2018 | Web Date: February 1, 2018
Protein mirror images could generate long-lasting biologics
Peptide- and protein-based biologic drugs have a problem. Enzymes in the body called proteases break down the linkages between L-amino acids in natural peptides and proteins. As a result, biologics typically have short lifetimes in the body and need to be injected or infused instead of taken as pills.
Synthetic analogs of natural peptides and proteins consisting of D-amino acids are safe from proteases. But drugmakers can’t just change L-amino acids to D-amino acids because . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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